[Chapter Title]: Platelet Rich Plasma (PRP)
Saad Sami AlSogair
Dr Layla AlOnaizi Polyclinic, Department of Dermatology
Khobar, Eastern Province, Saudi Arabia
[Introduction/ Abstract: 1 paragraph, approx. 150-250 words, don’t include reference citations or undefined abbreviations) …]
Platelet-rich plasma is also known as autologous platelet gel, plasma-rich growth factors and platelet-concentrated plasma. They are abundant platelets that are concentrated into a small volume of plasma.
Various growth factors, including platelet-derived growth factor, transforming growth factor, vascular endothelial growth factor, and insulin-like growth factor are secreted from the alpha granules of concentrated platelets activated by aggregation inducers. These factors are known to regulate processes including cell migration, attachment, proliferation and differentiation, and promote extracellular matrix accumulation by binding to specific cell surface receptors. Platelet rich plasma is used in androgenetic alopecia, alopecia areata, skin rejuvenation, acne scars, contour defects, wound ulcers, connective tissue disease-associated ulcers, stria distensae, lipodermatosclerosus and lichen sclerosus. Platelet rich plasma can be administered through inter-follicular injection, as mesotherapy, as an adjunct to hair transplantation or as topical application under occlusion. It can also be used as direct intradermal injections and as an adjuvant to lasers or microneedling. Being an autologous preparation, it is devoid of any serious adverse effects, apart from local injection site reactions like pain or secondary infection, which can be avoided with proper precautions.